When not showing wheels in a BikeCAD drawing, you can tighten up the space around the frame to make better use of the sheet. To do this, recognize that the free space fields locate the borders of the drawing with respect to the edges of the wheels. Once the wheels are removed you can use negative values to bring the border inside the space where the wheels used to be.
Here I'll change the Free space on the left from 40mm to -200mm, the Free space on the right I'll set to -330mm and the Free space on the bottom I'll set to -20mm.
For convenience down the road, you may want to save these values in a title block template by selecting File >> Save template >> Title block and give it a name like "No wheels". Then you can always toggle back and forth between title block settings that are suited to the display of wheels and title block settings that are suited to bare frames.